Job Description

Principal Scientist - Genomics (Temporary Contract) Full-time Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. The purpose of this position is to develop high-throughput cutting-edge genomic technologies to better understand disease mechanisms and to accelerate the discovery of new targets and biomarkers across therapeutic areas. The incumbent will utilize innovative genetic screening (CRISPR) and multi-omics single cell sequencing approaches (Optical pooled screening, CRISPR-Seq) to impact all stages of the pipeline from pre-clinical to clinical development. In the position, you will collaborate closely with Oncology, Immunology, Neuroscience, Cardiometabolic disease, Pharmacology, and Chemical Biology areas throughout the Discovery, Preclinical and Translational Medicine. We are seeking a highly motivated scientist with expertise in cell and molecular biology, high-throughput genomic technologies, CRISPR screening, and high content imaging to join our group in Cambridge, MA. In this exciting role you will: Contribute to the planning and execution of experiments to discover new drug targets in multiple therapeutic areas. Work with complex cellular models (primary cells, iPSC-derived cells, 2D and 3D coculture models) in addition to immortalized cell lines. Assist in developing, executing, analyzing, and troubleshooting new cell-based assays with disease-relevant phenotypes and determine feasibility and the best approach for CRISPR screens. Execute large-scale CRISPR screens in pooled and arrayed formats. Use gene editing and other genomic technologies (transcriptomics, proteomics) to validate potential drug targets. Communicate results and findings clearly and concisely to teams and stakeholders. Maintain detailed lab notebook and records of work, help the lab manager maintain laboratory equipment used for experiments. This position requires 90% of time in the lab. Minimum Qualifications: Ph.D. degree in cell and molecular biology or related scientific discipline or M.S. degree in cell and molecular biology or related scientific discipline with 5+ years hands-on wet lab experience in academia or industry. Required Experience and Skills: Extensive hands-on experience in cell-based assay development, CRISPR-based screens. Working knowledge and experience with high-content imaging assays. Strong ability to troubleshoot and optimize novel methods and protocols. Self-motivated and capable of prioritizing deliverables among multiple simultaneous projects. Excellent attention to detail and strong communication skills. Ability to work independently, but also build strong relationships within highly collaborative, multidisciplinary teams to effectively drive early drug discovery initiatives. Preferred Experience and Skills: Demonstrated experience with high-content phenotypic screening. Image analysis tools experience (e.g. Signals Image Artist). Experience with genomic technologies (NGS, scRNA-seq, CROP-seq/Perturb-seq). Drug Discovery experience in biotech and/or pharmaceutical industry. Experience working in a highly matrixed organization. The position is a temporary role, Monday-Friday from 8am-5pm. Candidates living within a commutable distance of Boston, MA and the surrounding areas are encouraged to apply. Excellent full-time benefits including comprehensive medical coverage, dental, and vision options. Life and disability insurance. 401(k) with company match. Paid vacation and holidays. Eurofins is an M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer. #J-18808-Ljbffr Eurofins BioPharma Product Testing Ireland, Ltd.

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